Saturday, April 27, 2013

Fujifilm's Finepix JZ700 compact shoots for speed with 8 fps burst, 200 fps video

Fujifilm's JZ700 compact camera goes for performance with 8 fps shooting, 1080P video

Camera makers seem to be scrambling to equip their compact models with wireless options, all the better to work with the smartphones that are trying to replace them. Fujifilm's taking a different tack with the 14-megapixel FinePix JZ700 by going for raw performance instead, like 8 fps burst shooting and 1080/30p video, both quite rare in low-end compacts. You'll also get an 8x Fujinon lens equivalent to 24-192mm, optical image stabilization, a 2.7-inch, 230K-dot LCD, up to 3200 ISO sensitivity, numerous filters and, interestingly, 200 fps video capture -- though the resolution at that speed isn't specified and we can imagine it's pretty low. Still, the camera's already hit the streets for around £130 ($200) and we don't know of any other near time-stopping cameras you can grab for that sum.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/NsV8g_ruEWY/

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Friday, April 26, 2013

Mail Pilot updated with IMAP enabled Exchange accounts, bug fixes, and more (plus giveaway!)

Mail Pilot updated with IMAP enabled Exchange accounts, bug fixes, and more (plus giveaway!)

Mail Pilot has just received an update which adds the much requested support for Exchange accounts that are IMAP enabled. Other features in the update include an improved add account system, bug fixes, enhancements, and more. Mail Pilot was also nice enough to give us some codes to give out to our readers...

If you'd like to try out Mail Pilot now, you can download it via the link below. We've also been given six codes to give out to our readers. All you have to do is leave a comment below to enter. Winners will be announced next week!

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/kiEG-pwTeyk/story01.htm

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Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis

Apr. 25, 2013 ? Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of liver injury leading to fibrosis include chronic hepatitis virus infection, excess alcohol consumption and, increasingly, nonalcoholic steatohepatitis (NASH).

Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.

"Because there are currently no effective drugs for liver fibrosis, we believe our findings would open a new door for treatment," says senior author Ronald M. Evans, a professor in Salk's Gene Expression Laboratory and lead researcher in the Institute's new Helmsley Center for Genomic Medicine.

The Salk study focused on a star-shaped "stellate" cell in the liver that serves as a beacon for damage. When called into action, stellate cells produce fibrotic proteins in an attempt to heal an injury. Under chronic stress, however, localized fibrosis expands, eventually leading to cirrhosis, increased risk of liver cancer, and the need for a liver transplant in advanced cases.

The Evans lab discovered a genetic switch through which vitamin D-related ligands such as calcitriol, a hormonally active form of the vitamin, can put the brakes on fibrosis. "Preclinical results suggest the 'vitamin D brake' is highly efficacious and led us to believe that the time is right to consider a trial in the context of chronic liver disease," says Evans, a Howard Hughes Medical Institute Investigator and holder of the March of Dimes Chair in Molecular and Developmental Biology.

Previous studies have shown a physiologic role for vitamin D in liver function, but "it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis," says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

"Current therapeutic approaches, which treat the symptoms of liver disease, don't stop liver fibrosis from progressing," says Michael Downes, a senior staff scientist in the Gene Expression Laboratory and co-corresponding author on the paper. "In liver diseases where the underlying cause cannot be cured, progression to cirrhosis is currently inevitable in some people. What we have discovered is that by acting on the genome, VDR can simultaneously defend against multiple fibrotic activators. This is important because many different pro-fibrotic signaling pathways converge on the genome to affect their fibrotic response."

The Salk discovery that calcipotriol counters the fibrotic response in stellate cells illuminates a potentially safer, more effective strategy capable of neutralizing multiple convergent fibrotic triggers.

The Salk scientists say that clinical trials of the vitamin D analog for the treatment of liver fibrosis are being planned. The synthetic vitamin D analog is better than natural vitamin D, they say, for a couple of reasons. First, natural vitamin D, which is found in small amounts in a few foods and produced in the body by exposure to sunlight, degrades quickly, while synthetic versions of vitamin D are less susceptible to breakdown. Second, too much natural vitamin D can cause hypercalcemia, or elevated calcium in the blood, which can lead to nausea and vomiting, frequent urination, muscle weakness and joint aches and pain. The synthetic vitamin D analog, on the other hand, produces a strong response without adding calcium to the blood.

In addition, the researchers say this new model for treating liver fibrosis may also be helpful in treating other diseases with a fibrotic component, including those of the lung, kidney and pancreas.

Other researchers on the study were Ruth T. Yu, Mara H. Sherman, Mathias Leblanc, Mingxiao He, Annette R. Atkins and Grant D. Barish, from the Salk Institute; Nanthakumar Subramaniam, Caroline Wilson, Renuka Rao, Sally Coulter and Christopher Liddle, of the University of Sydney (Australia); and Sue L. Lau , Christopher Scott and Jenny E. Gunton, of the Garvan Insitute for Medical Research (Australia).

The work was supported by grants from the National Institutes of Health, the Howard Hughes Medical Institute, the National Health and Medical Research Council of Australia, the Genentech Foundation, the Leona M. and Harry B. Helmsley Charitable Trust, the Samuel Waxman Cancer Research Foundation, Stand Up to Cancer and Ipsen/Biomeasure.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/GZLOXi4a8Bo/130425160125.htm

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Examine social factors to explain rise in diagnoses of mental disorders

Apr. 25, 2013 ? Examining social factors is vital to better explaining and understanding the dramatic rise in the number of Americans diagnosed with mental disorders in recent years, according to an analysis by a team of medical and mental health experts.

Their conclusions, which appear in the latest issue of the journal Health Affairs, comes ahead of the May release of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-5), a comprehensive guide that sets the classification, diagnosis, and treatment of mental disorders across the United States and the world.

The study included researchers from New York University, Columbia University, the University of California, Berkeley, and Rutgers University.

In their analysis and commentary, the authors argue that the forthcoming DSM-5, which is used by all psychiatrists, psychologists, and mental health workers in the U.S., has missed crucial population-level and social determinants of mental health disorders and their diagnosis. As a result, the DSM may be mischaracterizing the rates of certain afflictions.

"If we are to believe current reports, there are 12 times more children with Attention Deficit Hyperactivity Disorder (ADHD) in the U.S. than in Europe, and within the U.S., there are almost 50 percent more children with ADHD today than a decade ago, according to DSM," observes the article's lead author, Helena Hansen, MD, PhD, an assistant professor of anthropology at NYU and an assistant professor of psychiatry at NYU Langone Medical Center. "My colleagues and I wanted to know if there was something else behind this."

"To explore this, we assembled a group of population health experts to identify the best way to explain the rise in these diagnoses. And what we found was that the clinical authorities in psychiatry who revise the DSM are unable to take into account other forces that drive the diagnosis of mental disorders."

To address this matter, the researchers posed three possible causes of the rise in diagnoses that are not currently accounted for in revisions of the DSM:

* Is there a change in the environment causing an actual increase in the mental health problem? For example, have the pressures of standardized testing in the U.S. caused ADHD symptoms?

* Are the diagnostic criteria applied differently depending on the institutional and social environment? For instance, do the increasing numbers of children diagnosed with ADHD reflect pharmaceutical company promotion of ADHD awareness and ADHD medications among school teachers and parents? Among low income children, do diagnoses reflect their effort to qualify for disability benefits in the wake of welfare reform?

* Are the diagnostic criteria written in a way that includes people who do not have a disorder? For example, do the criteria for ADHD of excessive running, climbing, and talkativeness describe a high level of energy that should be expected among children?

The researchers also propose an independent review of these factors.

"To sort out which these three factors causes differences in the diagnosis of a mental disorder over time and place, we need a review body that acts independently of the authors of the DSM and that is composed of experts on population health and the social factors driving mental health," says Hansen. "Using the example of ADHD, the review body might look at the number of children diagnosed under different educational and welfare policies -- and before and after pharmaceutical promotions. It might also examine how changes to the criteria for ADHD in each revision of the DSM affect the number of children given the diagnosis."

"By charging experts with independent review of the best available research on population and social variation in the diagnosis of mental disorders, we can identify unconsidered but powerful causes of diagnosis and inform future revisions of the DSM."

The analysis, which was supported by the Robert Wood Johnson Health and Society Scholars Program, will appear in the May issue of Health Affairs.

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Journal Reference:

  1. H. B. Hansen, Z. Donaldson, B. G. Link, P. S. Bearman, K. Hopper, L. M. Bates, K. Cheslack-Postava, K. Harper, S. M. Holmes, G. Lovasi, K. W. Springer, J. O. Teitler. Independent Review Of Social And Population Variation In Mental Health Could Improve Diagnosis In DSM Revisions. Health Affairs, 2013; DOI: 10.1377/hlthaff.2011.0596

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/DSGJOdAw25g/130425103200.htm

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Twitter reportedly working on location-based discovery tool

Twitter reportedly working on locationbased discovery tool

The next big Twitter feature? Finding out what your neighbor's talking about, 140 characters at a time, of course. According to All Things D, the service is working on exactly that, a location-based feature that was reportedly developed at a hack week held by the company earlier this month. Twitter, predictably, isn't commenting on the reportedly upcoming feature, but D has says that this information is coming from "multiple sources." No word on how close they all are to one another.

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Source: All Things D

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/uvMM3ax_k2A/

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How a phony tweet and computer trades sank stocks

NEW YORK (AP) ? For a few surreal minutes, a mere 12 words on Twitter caused the world's mightiest stock market to tremble.

No sooner did hackers send a false Associated Press tweet reporting explosions at the White House on Tuesday than investors started dumping stocks ? eventually unloading $134 billion worth. Turns out, some investors are not only gullible, they're impossibly fast stock traders.

Except most of the investors weren't human. They were computers, selling on autopilot beyond the control of humans, like a scene from a sci-fi horror film.

"Before you could blink, it was over," said Joe Saluzzi, co-founder of Themis Trading and an outspoken critic of high-speed computerized trading. "With people, you wouldn't have this type of reaction."

For decades, computers have been sorting through data and news to help investment funds decide whether to buy or sell. But that's old school. Now "algorithmic" trading programs sift through data, news, even tweets, and execute trades by themselves in fractions of a second, without slowpoke humans getting in the way. More than half of stock trading every day is done this way.

Markets quickly recovered after Tuesday's plunge. But the incident rattled traders and highlighted the danger of handing control to the machines.

"It's easy to plant a false rumor with machines in their current state," said Irene Aldridge, a consultant to hedge funds on algorithmic programs who teaches computer trading at New York University. She said most trading programs that read news just count the number of positive and negative words, without any filter.

Regulators have complained that these trading programs make it difficult for them to ensure markets don't misfire.

Just how exactly the trading unfolded Tuesday is still a bit of mystery.

Some experts say the computers took their cue from humans, picking up on a pause in buying as traders read the phony tweet. In Wall Street's insanely fast trading world, humans holding back for even a second could have signaled to computers that buyers were drying up and that prices could fall, and so the computers should sell fast.

Others, like Saluzzi, think computers may have sold on the tweet itself. That's possible because computer trading programs are increasingly written to read, and react to, news from social media outlets like Twitter.

Experts say the fake tweet seemed designed to catch a computer's attention.

Ron Brown, head of Elektron Analytics, a Thomson-Reuters unit that sells news feeds that computers can read, said that the words "explosions" or "Obama" alone wouldn't have triggered selling. But add "White House," and it's a combination even the slowest computer couldn't miss.

Brown said his service doesn't include Twitter in its feeds because there's too much useless "noise" in the deluge of tweets and, given the 140-character limit to tweets, often too little context.

Before the fake tweet appeared on Tuesday, it looked like any other good day on Wall Street. Unexpectedly strong earnings reports from Netflix and DuPont sent the Standard and Poor's 500 stock index up 1 percent at 1,578 with three hours to go in the trading day.

Then, at 1:08 p.m. EDT, a tweet appeared on the hacked AP Twitter account stating that two explosions at the White House had injured President Barack Obama. Stocks immediately started falling, and kept doing so for two minutes. AP quickly announced that its account had been hijacked and the report was false. Prices began to climb again.

A group called the Syrian Electronic Army said it was responsible for the hack. But the claim has not been corroborated. The FBI has opened an investigation into the incident, spokeswoman Jenny Shearer said.

Whoever was responsible, the damage was big. The Dow lost 143 points, or 1 percent, in two minutes. In the frenzied selling, oil prices dropped, gold rose, the dollar rallied and the price of Treasurys, seen by many investors as a hiding spot, shot higher, briefly knocking yields to their lowest level of the year.

Some Wall Street pros were surprised that a single tweet could move markets so much.

Julian Brigden, managing partner of Macro Intelligence 2 Partners, an investment consultancy, said the drop suggested an "unstable" trading environment dominated by investors too quick to buy or sell without any thought.

"To me, it's indicative of a very dangerous market," he said.

Though stocks eventually recovered for the day, investors have been on edge recently.

Both the S&P 500 and the Dow Jones industrial average lost 2 percent last week, their biggest weekly drops in five months. Investors were reacting to slowing Chinese economic growth, plunging commodity prices and mixed earnings reports from big U.S. companies. A measure of likely future swings in stocks ? what's known as the "fear" index, or VIX ? jumped 40 percent at one point last week.

The Boston Marathon bombing added to the jitters.

"People are looking for a reason to sell, and (Tuesday) it was a fake Tweet," said Adam Sussman, head of research at Tabb Group, a research firm. "Of course, once they realized it was fake, they bought back in, or they stopped selling."

But he thinks humans played only a minor role in stock plunge. He said most professional investors are too savvy to sell on a tweet.

"They'd get a tweet from AP and then say, 'Oh, was there a corroborating tweet from Bloomberg? A corroborating tweet from Thomson Reuters?' and so forth," he said. "So I don't believe that anyone selling substantial money saw that tweet and just began selling off billions of dollars."

Joe Fox, founder of online brokerage Ditto Trade, said the selling was too fast for humans to have pulled off, and computers were to blame.

"Whoever this jerk (who wrote the tweet) is probably cost some people millions of dollars in a matter of minutes," he said.

Computer programs have come to dominate stock-market trading over the past 20 years. The goal is speed, and it's led to an arms race as companies develop ever-faster programs. High-frequency trading came under public scrutiny following the "flash crash" of May 6, 2010, when a glitch erased 600 points from the Dow Jones industrial average in five minutes.

One of the latest weapons in the arms race is machine-readable news. The Thomson Reuters service, one of the more popular offerings, scans 50,000 news sources and 4 million social media sites for stories.

Brown of Thomson Reuters says his programs take news articles and announcements and automatically flag answers to the essential questions ? who, what, where, when and why. The answers are translated into a code that an investment firm's trading program can understand and then sent to clients. All of that takes less than one-thousandth of a second.

It's up to the investment fund to place a value on each word and rank established news outlets over other sources like blogs or social media websites, Brown said.

Tapping into the stream of comments on Twitter has become increasingly popular. Earlier this month, the Securities and Exchange Commission cleared companies to release key announcements on Twitter, Facebook and other social-media venues. Bloomberg also added Twitter to its terminal, a fixture on every big bank's trading floor.

Johan Bollen, an associate professor of informatics and computing at Indiana University, said Twitter is more useful for getting a sense of public opinion. A study he co-authored in 2010 tied the overall mood of tweets to the direction of the Dow Jones industrial average and made a splash among managers of hedge funds.

But Bollen warned that mood is one thing, news is another.

"If you want to trade on the news from Twitter, you run the risk of trading on false data, even deliberately false data."

Regulators have been studying the problems posed by automatic computer trading for years. Last month, the SEC proposed tighter oversight of automatic trading. Stock exchanges would be required to test their trading systems routinely, and report to the SEC about problems that could damage trading, like hacking.

Aldridge, the computer trading consultant, said regulators should beef up their monitoring of Twitter, but that glitches and plunges may be inevitable in the brave new digital age. "You can't ban Twitter," she said.

Bart Chilton, a member of the Commodity Futures Trading Commission, another regulator overseeing markets, said government investigators will find that high-speed trading programs "will have been all over this trading time period."

The CFTC has been examining high-speed programs to gauge their importance in the markets and consider possible new rules for them.

"The exchanges love speed," Chilton said. "I'm not so sure that fast is always better."

___

Associated Press writers Christina Rexrode in New York and Marcy Gordon in Washington contributed to this report.

Source: http://news.yahoo.com/phony-tweet-computer-trades-sank-stocks-201916964--finance.html

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Thursday, April 25, 2013

High-nutrition and disease-resistant purple and yellow-fleshed potato clones obtained

Apr. 24, 2013 ? The Basque Institute for Agricultural Research and Development, Neiker-Tecnalia, has created four new potato clones which are characterised by their high antioxidant content, their good production both in size and number of tubers, as well as by their resistance to the usual diseases of this crop. The clones were obtained by natural methods through crossing varieties from South America with commercial varieties used in Europe. The result was three clones of the purple-fleshed potato and one with a markedly yellow flesh. The attractiveness and nutritional value of these types of potato make them a product highly regarded by professionals in gastronomy and by the public in general.

The work of creating the clones is part of the Potato Genetic Enhancement Programme drawn up by Neiker-Tecnalia. The research was led by agricultural engineer Ms Raquel L?pez, being the basis for her PhD thesis, and was presented at the University of the Basque Country. The aim of this specialist was to find potatoes which brought together the features of the South American varieties (their colour, resistance to pathogens and their nutritional and organoleptic properties) with those of the commercial varieties employed in our latitudes and characterized by their high productivity.

The Neiker-Tecnalia researchers brought 37 varieties from the Centro Internacional de la Papa, based in Peru. These native South American varieties were crossed in the greenhouse with commercial varieties, using natural procedures. The selection of and crossing between individuals with the best traits has given rise to the four clones mentioned. For the moment, these involve advanced clones and not commercial varieties, as they are not registered at the Spanish Office for Plant Varieties (OEVV in the Spanish acronym) or the European Community Plant Variety Office (CPVO). The process of registering is a long one, lasting about 15 years.

The varieties imported from Peru have a very low productivity in our latitudes, both in size and the number of tubers. Nevertheless, with the process of crossing and selection, the final clones having acceptable productivity has been achieved.

Nutritional value and resistant to pathogens

The four clones obtained are characterised by the high presence of antioxidants compounds, making them very attractive from a nutritional perspective. The three purple-flesh clones contain a large quantity of anthocyanins ? a highly appreciated pigment in the preparation of high added value foods ?, while the yellow flesh variety have carotenes ? essential chemical components for the diet ? and in greater quantities than in the usual commercial varieties.

Resistance to diseases is another of the achievements. The four clones show certain resistance to the pathogens analysed, such as the potato virus Y, as well as the Pectobacterium atrosepticum bacteria, which weaken the vegetable and considerably undermine its production.

Researcher Raquel L?pez highlights the importance of taking into account the clones achieved. ?It is beneficial for European producers to have varieties of purple flesh potato that are adapted to the climatological conditions of this continent. Moreover, these varieties incorporate natural antioxidant compounds, which are nutritionally and visually attractive, both for restaurant professionals and for end consumers?.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/i5mIBlRVxmw/130424081058.htm

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